It is then converted with 8-methyl-6-nonenoic acid into capsaicin by the enzyme capsaicin synthase.
2.
By installing a Boc protecting group at the C-4 amide nitrogen, the Boehringer-Ingelheim chemists were able to shift the site of initiation from the vinylcyclopropane moiety to the nonenoic acid moiety, improving the rate of the intramolecular reaction and decreasing the risk of epimerization.
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